Free NAPLEX Sample Questions
See why TrueLearn is a trusted resource for thousands of pharmacy students. At TrueLearn, we understand that it’s all about the content. That’s why we have high-yield pharmacy practice questions written and screened by high-performing pharmacist authors that are updated on a regular basis to ensure our SmartBanks stay up-to-date with exam blueprint changes. Below are two free NAPLEX sample questions so you can see what we mean.
Your First Free NAPLEX Sample Question
Ms. Mide, a 21-year-old woman, is interested in getting the human papillomavirus vaccine (Gardasil9). Which of the following is the correct regimen?
- A. She should get two doses total, one at month 0 and one between month 6 and month 12
- B. She should get three doses total, one at each of months 0, 4, and 6
- C. She should get two doses total, one at each of months 0 and 6
- D. She should get three doses total, one at month 0, one between month 1 and month 2, and one at month 6
- E. The vaccine is not appropriate to administer to this patient because of her age
The Answer and Explanation
Did you get it right? The correct answer is: D
Human papillomavirus (HPV) vaccine (Gardasil9 [9-valent, recombinant]) helps to protect individuals who are 9 to 45 years of age against the following diseases, which are caused by nine types of HPV:
- cervical, vaginal, and vulvar cancers in female patients; and
- anal cancer and genital warts in both male and female patients.
It may be given as two or three shots.For persons who are 15 through 45 years of age, Gardasil9 is given using a three-dose schedule; the second shot should be given two months after the first shot, and the third shot should be given six monthsafter the first shot.
| Patient Age | Two-Dose Schedule | Three-Dose Schedule |
| 9 – 14 years | The second shot should be given six to twelve months after the first shotIf the second shot is given less than five months after the first shot, a third shot should be given at least four months after the second shot | The second shot should be given two months after the first shotThe third shot should be given six months after the first shot |
| 15 – 45 years | N/A | The second shot should be given two months after the first shotThe third shot should be given six months after the first shot |
Incorrect Answer Explanations
Answer A: Two doses, one at month 0 and one between month 6 and month 12, is the two-dose regimen that is used if vaccination is started before the patient is 15 years of age. This regimen would not be appropriate for Ms. Mide, who is 21 years of age.
Answer B: Three doses total, one at each of months 0, 4, and 6, is not an option for administering human papillomavirus vaccine (Gardasil9) to patients of any age.
Answer C: Two doses total, one at each of months 0 and 6, is not an option for administering human papillomavirus vaccine (Gardasil) to patients of any age.
Answer E: Human papillomavirus vaccine (Gardasil9) is appropriate for Ms. Mide, because her age is 21 years.
Bottom Line
All nonsteroidal anti-inflammatory drugs (NSAIDs), including celecoxib (Celebrex) have US Boxed Warnings for an increased risk of serious adverse cardiovascular thrombotic events, including myocardial infarction and stroke.
For more information, see:
GARDASIL®9 (Human Papillomavirus 9-valent Vaccine, Recombinant) | Official Site. (2019). Retrieved 22 November 2019.
DiPiro. Pharmacotherapy: A Pathophysiologic Approach, 11e. Chapter 142: Vaccines and Immunoglobulins.
Your Second Free NAPLEX Sample Question
This diagram depicts the mechanism of action of acetylcysteine in the treatment of acetaminophen (Tylenol) toxicity. Which of the compounds in this diagram is toxic?
A. Glucuronide moiety
B. Sulfate moiety
C. N-acetyl-p-benzoquinone imine (NAPQI)
D. Glutathione
E. Cysteine and mercapturic-acid conjugates
The Answer and Explanation
Did you get it right? The correct answer is: C
Acetylcysteine, also known as N-Acetylcysteine or NAC, is the drug of choice for the treatment of acetaminophen (Tylenol) overdose or toxicity. It is a hepatoprotective agent that restores glutathione in the liver and enhances the non-toxic sulfate conjugation of Tylenol. It does this by providing cysteine for glutathione (non-toxic) synthesis and by forming an adduct with the toxic metabolite of tylenol, N-acetyl-p-benzoquinone imine, which ultimately forms the non-toxic cysteine and mercapturic-acid conjugates. The glucuronide and sulfate moieties that form during Tylenol metabolism are non-toxic.
Incorrect Answer Explanations
Answer A: The glucuronide moiety that forms during acetaminophen (Tylenol) metabolism is non-toxic.
Answer B: The sulfate moiety that forms during acetaminophen (Tylenol) metabolism is non-toxic.
Answer D: The glutathione provided by acetylcysteine is non-toxic.
Answer E: The cysteine and mercapturic-acid conjugates are non-toxic.
Bottom Line
Acetylcysteine provides cysteine for glutathione (non-toxic) synthesis and forms an adduct with the toxic metabolite of acetaminophen (Tylenol), N-acetyl-p-benzoquinone imine, which ultimately forms the non-toxic cysteine and mercapturic-acid conjugates.
For more information, see:
UpToDate: Acetylcysteine: Drug information.Lauterburg BH, Corcoran GB, Mitchell JR. Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Investig. 1983;71(4):980–991.
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